A team of engineers has shown that surface diffusion in protein transport into ion-exchange beads depends on adsorption affinity — a measure of attraction between the two materials.
UD engineers uncover role of surface diffusion in protein transport, which could aid biopharmaceutical processing
A team of engineers from the University of Delaware, with a collaborator from pharmaceutical company Amgen, has shown that surface diffusion in protein transport into ion-exchange beads depends on adsorption affinity — a measure of attraction between the two materials. By exploiting this relationship, the team developed a procedure to purify a monoclonal antibody — a type of molecule that mediates immunity — with productivity 43% higher than usual.